A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon α

A cancer treatment is described in which i.m. injection of plasmid DNA (pDNA) encoding murine interferon α (mIFN-α) leads to potent antitumor effects on primary and metastatic tumors in mice. Mice bearing s.c. B16F10 melanoma, Cloudman melanoma, or glioma 261 tumors were injected i.m. with mIFN-α pD...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Horton, Holly M., Anderson, Deborah, Hernandez, Pepe, Barnhart, Kerry M., Norman, Jon A., Parker, Suezanne E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15514/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990062/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1553
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