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A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon α

A cancer treatment is described in which i.m. injection of plasmid DNA (pDNA) encoding murine interferon α (mIFN-α) leads to potent antitumor effects on primary and metastatic tumors in mice. Mice bearing s.c. B16F10 melanoma, Cloudman melanoma, or glioma 261 tumors were injected i.m. with mIFN-α pD...

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Detalhes bibliográficos
Main Authors: Horton, Holly M., Anderson, Deborah, Hernandez, Pepe, Barnhart, Kerry M., Norman, Jon A., Parker, Suezanne E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15514/
https://ncbi.nlm.nih.gov/pubmed/9990062
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