Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes

The accessory protein Nef plays a crucial role in primate lentivirus pathogenesis. Nef enhances human immunodeficiency virus type 1 (HIV-1) infectivity in culture and stimulates viral replication in primary T cells. In this study, we investigated the relationship between HIV-1 replication efficiency...

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Hlavní autoři: Lundquist, Christopher A., Tobiume, Minoru, Zhou, Jing, Unutmaz, Derya, Aiken, Christopher
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC155097/
https://ncbi.nlm.nih.gov/pubmed/11932428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.9.4625-4633.2002
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