Proline 78 Is Crucial for Human Immunodeficiency Virus Type 1 Nef To Down-Regulate Class I Human Leukocyte Antigen

Human immunodeficiency virus type 1 Nef down-regulates human leukocyte antigen class I (HLA-I) in T lymphocytes, and the down-regulation involves the Nef proline-rich domain (PRD) containing four prolines at positions 69, 72, 75, and 78. We used a Sendai virus vector with nef and examined regulation...

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Detalhes bibliográficos
Main Authors: Yamada, Takeshi, Kaji, Naotoshi, Odawara, Takashi, Chiba, Joe, Iwamoto, Aikichi, Kitamura, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140770/
https://ncbi.nlm.nih.gov/pubmed/12502873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1589-1594.2003
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