Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis

The absence of immune defects that occurs in the syndrome of long-term nonprogressive (LTNP) HIV infection offers insights into the pathophysiology of HIV-induced immune disease. The (H[F/S]RIG)(2) domain of viral protein R (Vpr) induces apoptosis and may contribute to HIV-induced T cell depletion....

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Hauptverfasser: Lum, Julian J., Cohen, Oren J., Nie, Zilin, Weaver, Joel G., Gomez, Timothy S., Yao, Xiao-Jian, Lynch, David, Pilon, André A., Hawley, Nanci, Kim, John E., Chen, Zhaoxia, Montpetit, Michael, Sanchez-Dardon, Jaime, Cohen, Eric A., Badley, Andrew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC155040/
https://ncbi.nlm.nih.gov/pubmed/12750404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316233
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