Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of hypoxia-inducible factor–1α (HIF-1α), which mediates the cellular response to hypoxia by increasing expression of genes involved in e...

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Autors principals: Brusselmans, Koen, Compernolle, Veerle, Tjwa, Marc, Wiesener, Michael S., Maxwell, Patrick H., Collen, Désiré, Carmeliet, Peter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC155039/
https://ncbi.nlm.nih.gov/pubmed/12750401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200315496
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