Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of hypoxia-inducible factor–1α (HIF-1α), which mediates the cellular response to hypoxia by increasing expression of genes involved in e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brusselmans, Koen, Compernolle, Veerle, Tjwa, Marc, Wiesener, Michael S., Maxwell, Patrick H., Collen, Désiré, Carmeliet, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2003
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC155039/
https://ncbi.nlm.nih.gov/pubmed/12750401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200315496
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