Upregulation of IFN-γ Receptor Expression by Proinflammatory Cytokines Influences IDO Activation in Epithelial Cells

Interferon-γ (IFN-γ) induces the enzyme indoleamine dioxygenase (IDO) in a variety of human cell types. Furthermore, tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) synergistically increase IFN-induced IDO activity. Inasmuch as cytokines can upregulate cytokine receptor expression, one mech...

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Hauptverfasser: SHIREY, KARI ANN, JUNG, JOO-YONG, MAEDER, GREGORY S., CARLIN, JOSEPH M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1550344/
https://ncbi.nlm.nih.gov/pubmed/16426148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2006.26.53
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