Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A

Cardiac hypertrophy is a common and often lethal complication of arterial hypertension. Atrial natriuretic peptide (ANP) has been postulated to exert local antihypertrophic effects in the heart. Thus, a loss of function of the ANP receptor guanylyl cyclase-A (GC-A) might contribute to the increased...

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Main Authors: Holtwick, Rita, van Eickels, Martin, Skryabin, Boris V., Baba, Hideo A., Bubikat, Alexander, Begrow, Frank, Schneider, Michael D., Garbers, David L., Kuhn, Michaela
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC154444/
https://ncbi.nlm.nih.gov/pubmed/12727932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317061
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