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Ligand Detection and Discrimination by Spatial Relocalization: A Kinase-Phosphatase Segregation Model of TCR Activation
We develop a model of tyrosine phosphorylation and activation of the T-cell receptor (TCR) by localization to regions of close membrane-membrane proximity (close contact) that physically exclude tyrosine phosphatases such as CD45. Phosphatase exclusion generates regions of low phosphatase and high k...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Biophysical Society
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1544308/ https://ncbi.nlm.nih.gov/pubmed/16751250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.080044 |
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