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A network of protein interactions determines polyglutamine toxicity

Several neurodegenerative diseases are associated with the toxicity of misfolded proteins. This toxicity must arise from a combination of the amino acid sequences of the misfolded proteins and their interactions with other factors in their environment. A particularly compelling example of how profou...

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Detalhes bibliográficos
Main Authors: Duennwald, Martin L., Jagadish, Smitha, Giorgini, Flaviano, Muchowski, Paul J., Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544172/
https://ncbi.nlm.nih.gov/pubmed/16832049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604548103
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