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Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
Protein misfolding, whether caused by aging, environmental factors, or genetic mutations, is a common basis for neurodegenerative diseases. The misfolding of proteins with abnormally long polyglutamine (polyQ) expansions causes several neurodegenerative disorders, such as Huntington’s disease (HD)....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2600758/ https://ncbi.nlm.nih.gov/pubmed/19015277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1673408 |
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