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Flanking sequences profoundly alter polyglutamine toxicity in yeast
Protein misfolding is the molecular basis for several human diseases. How the primary amino acid sequence triggers misfolding and determines the benign or toxic character of the misfolded protein remains largely obscure. Among proteins that misfold, polyglutamine (polyQ) expansion proteins provide a...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1544171/ https://ncbi.nlm.nih.gov/pubmed/16832050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604547103 |
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