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Acidic pH induces topoisomerase II-mediated DNA damage

Acidic pH plays an important role in various pathophysiological states and has been demonstrated to be carcinogenic in animal models. Recent studies have also implicated acidic pH in the development of preneoplastic Barrett's esophagus in human. However, little is known about the molecular mech...

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Bibliografische gegevens
Hoofdauteurs: Xiao, Hai, Li, Tsai-Kun, Yang, Jin-Ming, Liu, Leroy F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2003
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC154323/
https://ncbi.nlm.nih.gov/pubmed/12692309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0935978100
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