Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells

Antiandrogens given to antagonize androgen receptor (AR) activity gradually lose their efficacy as antagonists and eventually function as agonists to promote (instead of block) AR-mediated growth of prostate cancer cells. The mechanisms of how antiandrogens acquire this agonist activity during hormo...

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Bibliografiske detaljer
Main Authors: Rahman, Mujib M., Miyamoto, Hiroshi, Lardy, Henry, Chang, Chawnshang
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC154309/
https://ncbi.nlm.nih.gov/pubmed/12700349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0530097100
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