Differentiation of Varicella-Zoster Virus ORF47 Protein Kinase and IE62 Protein Binding Domains and Their Contributions to Replication in Human Skin Xenografts in the SCID-hu Mouse

To investigate the role of the ORF47 protein kinase of varicella-zoster virus (VZV), we constructed VZV recombinants with targeted mutations in conserved motifs of ORF47 and a truncated ORF47 and characterized these mutants for replication, phosphorylation, and protein-protein interactions in vitro...

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Main Authors: Besser, Jaya, Sommer, Marvin H., Zerboni, Leigh, Bagowski, Christoph P., Ito, Hideki, Moffat, Jennifer, Ku, Chia-Chi, Arvin, Ann M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2003
主題:
Replication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC154036/
https://ncbi.nlm.nih.gov/pubmed/12719588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5964-5974.2003
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