Elimination of Protease Activity Restores Efficient Virion Production to a Human Immunodeficiency Virus Type 1 Nucleocapsid Deletion Mutant

The nucleocapsid (NC) region of human immunodeficiency virus type 1 (HIV-1) Gag is required for specific genomic RNA packaging. To determine if NC is absolutely required for virion formation, we deleted all but seven amino acids from NC in a full-length NL4-3 proviral clone. This construct, DelNC, p...

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Detalhes bibliográficos
Main Authors: Ott, David E., Coren, Lori V., Chertova, Elena N., Gagliardi, Tracy D., Nagashima, Kunio, Sowder II, Raymond C., Poon, Dexter T. K., Gorelick, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154014/
https://ncbi.nlm.nih.gov/pubmed/12719547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5547-5556.2003
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