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Mutations in the N-Terminal Region of Influenza Virus PB2 Protein Affect Virus RNA Replication but Not Transcription

PB2 mutants of influenza virus were prepared by altering conserved positions in the N-terminal region of the protein that aligned with the amino acids of the eIF4E protein, involved in cap recognition. These mutant genes were used to reconstitute in vivo viral ribonucleoproteins (RNPs) whose biologi...

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Udgivet i:J Virol
Principais autores: Gastaminza, Pablo, Perales, Beatriz, Falcón, Ana M., Ortín, Juan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153989/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12692212/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.9.5098-5108.2003
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