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Reduction of the Ganglioside Binding Activity of the Tetanus Toxin H(C) Fragment Destroys Immunogenicity: Implications for Development of Novel Tetanus Vaccines

In this study, the immunogenicities of the nontoxic H(C) fragment of tetanus toxin and derivatives lacking ganglioside binding activity were compared with that of tetanus toxoid after subcutaneous immunization of mice. Wild-type H(C) (H(C)WT) protein and tetanus toxoid both elicited strong antibody...

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書誌詳細
主要な著者: Qazi, Omar, Sesardic, Dorothea, Tierney, Robert, Söderbäck, Zahra, Crane, Dennis, Bolgiano, Barbara, Fairweather, Neil
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539629/
https://ncbi.nlm.nih.gov/pubmed/16861677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00500-06
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