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Reduction of the Ganglioside Binding Activity of the Tetanus Toxin H(C) Fragment Destroys Immunogenicity: Implications for Development of Novel Tetanus Vaccines
In this study, the immunogenicities of the nontoxic H(C) fragment of tetanus toxin and derivatives lacking ganglioside binding activity were compared with that of tetanus toxoid after subcutaneous immunization of mice. Wild-type H(C) (H(C)WT) protein and tetanus toxoid both elicited strong antibody...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1539629/ https://ncbi.nlm.nih.gov/pubmed/16861677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00500-06 |
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