Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function. A mutation of LAT (Y136F) that disrupts phospholipase C-γ1 activation and subsequent calcium influx causes a partial block in T cell development and leads to a severe lymphop...

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Main Authors: Sommers, Connie L., Lee, Jan, Steiner, Kevin L., Gurson, Jordan M., DePersis, Corinne L., El-Khoury, Dalal, Fuller, Claudette L., Shores, Elizabeth W., Love, Paul E., Samelson, Lawrence E.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538971/
https://ncbi.nlm.nih.gov/pubmed/15795236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041869
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