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Landscape approaches for determining the ensemble of folding transition states: Success and failure hinge on the degree of frustration

We present a method for determining structural properties of the ensemble of folding transition states from protein simulations. This method relies on thermodynamic quantities (free energies as a function of global reaction coordinates, such as the percentage of native contacts) and not on “kinetic”...

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書誌詳細
主要な著者: Nymeyer, Hugh, Socci, Nicholas D., Onuchic, José Nelson
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2000
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC15382/
https://ncbi.nlm.nih.gov/pubmed/10639131
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