Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice

Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the mouse, two proinsulin isoforms coexist. Most studies point to proinsulin 2 as the major isoform recognized by T cells in the NOD mouse. We studied mice in which a null proinsulin 2 mutation was transferred fr...

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Huvudupphovsmän: Thébault-Baumont, Karine, Dubois-Laforgue, Danielle, Krief, Patricia, Briand, Jean-Paul, Halbout, Philippe, Vallon-Geoffroy, Karine, Morin, Joëlle, Laloux, Véronique, Lehuen, Agnès, Carel, Jean-Claude, Jami, Jacques, Muller, Sylviane, Boitard, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2003
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC153768/
https://ncbi.nlm.nih.gov/pubmed/12639991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316584
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