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Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo

Neuronal cultures in vitro readily oxidized both D-[(14)C]glucose and l-[(14)C]lactate to (14)CO(2), whereas astroglial cultures oxidized both substrates sparingly and metabolized glucose predominantly to lactate and released it into the medium. [(14)C]Glucose oxidation to (14)CO(2) varied inversely...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Itoh, Yoshiaki, Esaki, Takanori, Shimoji, Kazuaki, Cook, Michelle, Law, Mona J., Kaufman, Elaine, Sokoloff, Louis
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153649/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12668764/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0831078100
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