Isometric contraction induces the Ca(2+)-independent activation of the endothelial nitric oxide synthase

Shear stress and tyrosine phosphatase inhibitors have been shown to activate the endothelial NO synthase (eNOS) in a Ca(2+)/calmodulin-independent manner. We report here that isometric contraction of rabbit aorta activates eNOS by a pharmacologically identical pathway. Endothelium-intact aortic ring...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Fleming, Ingrid, Bauersachs, Johann, Schäfer, Andreas, Scholz, Dimitri, Aldershvile, Jan, Busse, Rudi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927704/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.1123
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