Isometric contraction induces the Ca(2+)-independent activation of the endothelial nitric oxide synthase

Shear stress and tyrosine phosphatase inhibitors have been shown to activate the endothelial NO synthase (eNOS) in a Ca(2+)/calmodulin-independent manner. We report here that isometric contraction of rabbit aorta activates eNOS by a pharmacologically identical pathway. Endothelium-intact aortic ring...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Fleming, Ingrid, Bauersachs, Johann, Schäfer, Andreas, Scholz, Dimitri, Aldershvile, Jan, Busse, Rudi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927704/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.1123
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