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Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases

The binding between a PK and its target is highly specific, despite the fact that many different PKs exhibit significant sequence and structure homology. There must be, then, specificity-determining residues (SDRs) that enable different PKs to recognize their unique substrate. Here we use and furthe...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Li, Lewyn, Shakhnovich, Eugene I., Mirny, Leonid A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2003
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Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153578/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12679523/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0737647100
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