Engineering the proteolytic specificity of activated protein C improves its pharmacological properties

Human activated protein C (APC) is an antithrombotic, antiinflammatory serine protease that plays a central role in vascular homeostasis, and activated recombinant protein C, drotrecogin alfa (activated), has been shown to reduce mortality in patients with severe sepsis. Similar to other serine prot...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Berg, David T., Gerlitz, Bruce, Shang, Jing, Smith, Tommy, Santa, Paula, Richardson, Mark A., Kurz, Ken D., Grinnell, Brian W., Mace, Ken, Jones, Bryan E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 2003
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC153571/
https://ncbi.nlm.nih.gov/pubmed/12671072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0736918100
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