Engineering the proteolytic specificity of activated protein C improves its pharmacological properties

Human activated protein C (APC) is an antithrombotic, antiinflammatory serine protease that plays a central role in vascular homeostasis, and activated recombinant protein C, drotrecogin alfa (activated), has been shown to reduce mortality in patients with severe sepsis. Similar to other serine prot...

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Autori principali: Berg, David T., Gerlitz, Bruce, Shang, Jing, Smith, Tommy, Santa, Paula, Richardson, Mark A., Kurz, Ken D., Grinnell, Brian W., Mace, Ken, Jones, Bryan E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153571/
https://ncbi.nlm.nih.gov/pubmed/12671072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0736918100
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