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Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties
Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA. This loop is important for anchoring elongation factor (EF-G for prokaryote or eEF2 for eukaryote) in mRNA translocation. Translation is inhibit...
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| Publicado no: | Toxins (Basel) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7150887/ https://ncbi.nlm.nih.gov/pubmed/32182799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins12030167 |
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