A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

A low molecular weight nonpeptide compound, KRH-1636, efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor...

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Autori principali: Ichiyama, Kozi, Yokoyama-Kumakura, Sei, Tanaka, Yuetsu, Tanaka, Reiko, Hirose, Kunitaka, Bannai, Kenji, Edamatsu, Takeo, Yanaka, Mikiro, Niitani, Yoshiaki, Miyano-Kurosaki, Naoko, Takaku, Hiroshi, Koyanagi, Yoshio, Yamamoto, Naoki
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153550/
https://ncbi.nlm.nih.gov/pubmed/12642669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0630420100
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