Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: Indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17

Bruck syndrome is characterized by the presence of osteoporosis, joint contractures, fragile bones, and short stature. We report that lysine residues within the telopeptides of collagen type I in bone are underhydroxylated, leading to aberrant crosslinking, but that the lysine residues in the triple...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bank, Ruud A., Robins, Simon P., Wijmenga, Cisca, Breslau-Siderius, Liesbeth J., Bardoel, Alfons F. J., Van der Sluijs, Hans A., Pruijs, Hans E. H., TeKoppele, Johan M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15349/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.1054
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