Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice.

Groups of female MRL/MpJ-lpr/lpr mice received either saline or FK506 (tacrolimus; 2 mg/kg intraperitoneally) three times weekly, cyclophosphamide (CY; 20 mg/kg) once monthly, or both drugs from 8 weeks of age. Median survival for untreated and CY-treated mice was 26 weeks, and for FK506- and FK506...

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Autori principali: Woo, J, Wright, T M, Lemster, B, Borochovitz, D, Nalesnik, M A, Thomson, A W
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534278/
https://ncbi.nlm.nih.gov/pubmed/7535208
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