Rapid Detection of Pyrazinamide-Resistant Mycobacterium tuberculosis by a PCR-Based In Vitro System

Pyrazinamide (PZA), an analog of nicotinamide, is a prodrug for tuberculosis which requires conversion to the bactericidal compound pyrazinoic acid by bacterial pyrazinamidase activity. Mutations leading to a loss of pyrazinamidase activity cause PZA resistance in Mycobacterium tuberculosis. Thus, t...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Suzuki, Yasuhiko, Suzuki, Aya, Tamaru, Aki, Katsukawa, Chihiro, Oda, Hajime
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Mycobacteriology and Aerobic Actinomycetes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153375/
https://ncbi.nlm.nih.gov/pubmed/11825963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.501-507.2002
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi