Rapid Detection of Pyrazinamide-Resistant Mycobacterium tuberculosis by a PCR-Based In Vitro System

Pyrazinamide (PZA), an analog of nicotinamide, is a prodrug for tuberculosis which requires conversion to the bactericidal compound pyrazinoic acid by bacterial pyrazinamidase activity. Mutations leading to a loss of pyrazinamidase activity cause PZA resistance in Mycobacterium tuberculosis. Thus, t...

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Veröffentlicht in:	J Clin Microbiol
Hauptverfasser:	Suzuki, Yasuhiko, Suzuki, Aya, Tamaru, Aki, Katsukawa, Chihiro, Oda, Hajime
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Mycobacteriology and Aerobic Actinomycetes
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153375/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11825963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JCM.40.2.501-507.2002
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