Rapid Detection of Pyrazinamide-Resistant Mycobacterium tuberculosis by a PCR-Based In Vitro System

Pyrazinamide (PZA), an analog of nicotinamide, is a prodrug for tuberculosis which requires conversion to the bactericidal compound pyrazinoic acid by bacterial pyrazinamidase activity. Mutations leading to a loss of pyrazinamidase activity cause PZA resistance in Mycobacterium tuberculosis. Thus, t...

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Main Authors: Suzuki, Yasuhiko, Suzuki, Aya, Tamaru, Aki, Katsukawa, Chihiro, Oda, Hajime
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Mycobacteriology and Aerobic Actinomycetes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC153375/
https://ncbi.nlm.nih.gov/pubmed/11825963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.501-507.2002
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