The In Vivo Susceptibility of Leishmania donovani to Sodium Stibogluconate Is Drug Specific and Can Be Reversed by Inhibiting Glutathione Biosynthesis

Resistance to pentavalent antimonial (Sb(v)) agents such as sodium stibogluconate (SSG) is creating a major problem in the treatment of visceral leishmaniasis. In the present study the in vivo susceptibilities of Leishmania donovani strains, typed as SSG resistant (strain 200011) or SSG sensitive (s...

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Bibliographische Detailangaben
Hauptverfasser: Carter, K. C., Sundar, S., Spickett, C., Pereira, O. C., Mullen, A. B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC153333/
https://ncbi.nlm.nih.gov/pubmed/12709318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.5.1529-1535.2003
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