Resistance of Leishmania donovani to Sodium Stibogluconate Is Related to the Expression of Host and Parasite γ-Glutamylcysteine Synthetase

Sequencing studies showed that the γ-glutamylcysteine synthetase (γ-GCS) heavy chain genes from sodium stibogluconate (SSG)-resistant (SSG-R) and SSG-susceptible (SSG-S) Leishmania donovani strains were identical, indicating that SSG resistance was related to quantitative differences in γ-GCS expres...

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Detalhes bibliográficos
Main Authors: Carter, K. C., Hutchison, S., Henriquez, F. L., Légaré, D., Ouellette, M., Roberts, C. W., Mullen, A. B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346807/
https://ncbi.nlm.nih.gov/pubmed/16377672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.88-95.2006
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