Multiple Resistance Mechanisms among Aspergillus fumigatus Mutants with High-Level Resistance to Itraconazole

A collection of Aspergillus fumigatus mutants highly resistant to itraconazole (RIT) at 100 μg ml(−1) were selected in vitro (following UV irradiation as a preliminary step) to investigate mechanisms of drug resistance in this clinically important pathogen. Eight of the RIT mutants were found to hav...

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Detalhes bibliográficos
Main Authors: Nascimento, Adriana M., Goldman, Gustavo H., Park, Steven, Marras, Salvatore A. E., Delmas, Guillaume, Oza, Uma, Lolans, Karen, Dudley, Michael N., Mann, Paul A., Perlin, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153329/
https://ncbi.nlm.nih.gov/pubmed/12709346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.5.1719-1726.2003
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