Shiga-Like Toxin II Impairs Hepatobiliary Transport of Doxorubicin in Rats by Down-Regulation of Hepatic P Glycoprotein and Multidrug Resistance-Associated Protein Mrp2

We investigated the effect of Shiga-like toxin II (SLT-II), derived from Escherichia coli O157:H7, on the hepatobiliary excretion of doxorubicin, a substrate for P glycoprotein and the multidrug resistance-associated protein Mrp2, and on the expression of P glycoprotein and Mrp2 in rats. Histopathol...

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Detalhes bibliográficos
Main Authors: Hidemura, Kazuhiko, Zhao, Ying Lan, Ito, Katsuki, Nakao, Akimasa, Tatsumi, Yasuaki, Kanazawa, Hiroaki, Takagi, Kenzo, Ohta, Michio, Hasegawa, Takaaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153315/
https://ncbi.nlm.nih.gov/pubmed/12709333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.5.1636-1642.2003
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