Histidine and Aspartic Acid Residues Important for Immunoglobulin G Endopeptidase Activity of the Group A Streptococcus Opsonophagocytosis-Inhibiting Mac Protein

The secreted Mac protein made by serotype M1 group A Streptococcus (GAS) (designated Mac(5005)) inhibits opsonophagocytosis and killing of GAS by human polymorphonuclear neutrophils. This protein also has cysteine endopeptidase activity against human immunoglobulin G (IgG). Site-directed mutagenesis...

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Bibliographische Detailangaben
Hauptverfasser: Lei, Benfang, Liu, Mengyao, Meyers, Elishia G., Manning, Heather M., Nagiec, Michael J., Musser, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC153276/
https://ncbi.nlm.nih.gov/pubmed/12704162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.5.2881-2884.2003
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