Histidine and Aspartic Acid Residues Important for Immunoglobulin G Endopeptidase Activity of the Group A Streptococcus Opsonophagocytosis-Inhibiting Mac Protein

The secreted Mac protein made by serotype M1 group A Streptococcus (GAS) (designated Mac(5005)) inhibits opsonophagocytosis and killing of GAS by human polymorphonuclear neutrophils. This protein also has cysteine endopeptidase activity against human immunoglobulin G (IgG). Site-directed mutagenesis...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Lei, Benfang, Liu, Mengyao, Meyers, Elishia G., Manning, Heather M., Nagiec, Michael J., Musser, James M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Molecular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12704162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.5.2881-2884.2003
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