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Expression of H(C) Subunits from Clostridium botulinum Types C and D and Their Evaluation as Candidate Vaccine Antigens in Mice
Two proteins representing the heavy-chain subunits of botulinum neurotoxin types C and D were expressed in Escherichia coli, and their vaccine potential was evaluated. Mice were vaccinated with doses ranging from 0.5 to 10 μg and were challenged with 10 to 10(5) 50% lethal doses of toxin. For the ty...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC153265/ https://ncbi.nlm.nih.gov/pubmed/12704175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.5.2941-2944.2003 |
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