Rapid Immune Responses to a Botulinum Neurotoxin Hc Subunit Vaccine through In Vivo Targeting to Antigen-Presenting Cells

The clostridial botulinum neurotoxins (BoNTs) are the most potent protein toxins known. The carboxyl-terminal fragment of the toxin heavy chain (Hc) has been intensively investigated as a BoNT vaccine immunogen. We sought to determine whether targeting Hc to antigen-presenting cells (APCs) could acc...

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Auteurs principaux: White, David M., Pellett, Sabine, Jensen, Mark A., Tepp, William H., Johnson, Eric A., Arnason, Barry G. W.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2011
Sujets:
Microbial Immunity and Vaccines
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147575/
https://ncbi.nlm.nih.gov/pubmed/21576339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00166-11
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