Determinants within an 18-Amino-Acid U1A Autoregulatory Domain That Uncouple Cooperative RNA Binding, Inhibition of Polyadenylation, and Homodimerization

The human U1 snRNP-specific U1A protein autoregulates its own production by binding to and inhibiting the polyadenylation of its own pre-mRNA. Previous work demonstrated that a short sequence of U1A protein is essential for autoregulation and contains three distinct activities, which are (i) coopera...

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Detalhes bibliográficos
Main Authors: Guan, Fei, Palacios, Daphne, Hussein, Reem I., Gunderson, Samuel I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153202/
https://ncbi.nlm.nih.gov/pubmed/12697817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.9.3163-3172.2003
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