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The Third P-loop Domain in Cytoplasmic Dynein Heavy Chain Is Essential for Dynein Motor Function and ATP-sensitive Microtubule Binding

Sequence comparisons and structural analyses show that the dynein heavy chain motor subunit is related to the AAA family of chaperone-like ATPases. The core structure of the dynein motor unit derives from the assembly of six AAA domains into a hexameric ring. In dynein, the first four AAA domains co...

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Udgivet i:Mol Biol Cell
Principais autores: Silvanovich, Andre, Li, Min-gang, Serr, Madeline, Mische, Sarah, Hays, Thomas S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2003
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153106/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12686593/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E02-10-0675
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