Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain

By integrating convergent protein engineering and rational inhibitor design, we have developed an in vivo conditional protein knockout and/or manipulation technology. This method is based on the creation of a specific interaction interface between a modified protein domain and sensitized inhibitors....

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Dettagli Bibliografici
Autori principali: Wang, Huimin, Shimizu, Eiji, Tang, Ya-Ping, Cho, Min, Kyin, Maureen, Zuo, Wenqi, Robinson, Daphne A., Alaimo, Peter J., Zhang, Chao, Morimoto, Hiromi, Zhuo, Min, Feng, Ruiben, Shokat, Kevan M., Tsien, Joe Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153085/
https://ncbi.nlm.nih.gov/pubmed/12646704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0636870100
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