Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain

By integrating convergent protein engineering and rational inhibitor design, we have developed an in vivo conditional protein knockout and/or manipulation technology. This method is based on the creation of a specific interaction interface between a modified protein domain and sensitized inhibitors....

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Autors principals: Wang, Huimin, Shimizu, Eiji, Tang, Ya-Ping, Cho, Min, Kyin, Maureen, Zuo, Wenqi, Robinson, Daphne A., Alaimo, Peter J., Zhang, Chao, Morimoto, Hiromi, Zhuo, Min, Feng, Ruiben, Shokat, Kevan M., Tsien, Joe Z.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC153085/
https://ncbi.nlm.nih.gov/pubmed/12646704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0636870100
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