Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain

By integrating convergent protein engineering and rational inhibitor design, we have developed an in vivo conditional protein knockout and/or manipulation technology. This method is based on the creation of a specific interaction interface between a modified protein domain and sensitized inhibitors....

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Bibliographische Detailangaben
Hauptverfasser: Wang, Huimin, Shimizu, Eiji, Tang, Ya-Ping, Cho, Min, Kyin, Maureen, Zuo, Wenqi, Robinson, Daphne A., Alaimo, Peter J., Zhang, Chao, Morimoto, Hiromi, Zhuo, Min, Feng, Ruiben, Shokat, Kevan M., Tsien, Joe Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC153085/
https://ncbi.nlm.nih.gov/pubmed/12646704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0636870100
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