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Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain
By integrating convergent protein engineering and rational inhibitor design, we have developed an in vivo conditional protein knockout and/or manipulation technology. This method is based on the creation of a specific interaction interface between a modified protein domain and sensitized inhibitors....
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC153085/ https://ncbi.nlm.nih.gov/pubmed/12646704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0636870100 |
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