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Preorganization of molecular binding sites in designed diiron proteins

De novo protein design provides an attractive approach to critically test the features that are required for metalloprotein structure and function. Previously we designed and crystallographically characterized an idealized dimeric model for the four-helix bundle class of diiron and dimanganese prote...

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Autori principali: Maglio, Ornella, Nastri, Flavia, Pavone, Vincenzo, Lombardi, Angela, DeGrado, William F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC152997/
https://ncbi.nlm.nih.gov/pubmed/12655072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0730771100
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